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Map1btm1Prop
Targeted Allele Detail
Nomenclature
Symbol: Map1btm1Prop
Name: microtubule-associated protein 1B; targeted mutation 1, Friedrich Propst
MGI ID: MGI:3575407
Synonyms: MAP1B-, MAP1Bdelta93
Gene: Map1b  Location: Chr13:99421464-99516602 bp, - strand  Genetic Position: Chr13, 52.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97423
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details20.5 kb of sequence including codons 96-2389, comprising exons 3-5 and part of exon 6, were deleted upon the insertion of a neomycin resistance cassette. Transcripts containing exon 5 sequences were not found in analysis of mutants, and both heavy and light chain polypeptides were absent from immunoblots of mutants. Also absent were any truncated amino-terminal proteins encoded by exons 1 or 2. (J:97423)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map1b Mutation:  52 strains or lines available
References
Original:  J:97423 Meixner A, et al., MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system. J Cell Biol. 2000 Dec 11;151(6):1169-78
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory