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Sema4atm1Kik
Targeted Allele Detail
Nomenclature
Symbol: Sema4atm1Kik
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; targeted mutation 1, Hutoshi Kikutani
MGI ID: MGI:3575087
Gene: Sema4a  Location: Chr3:88435959-88459101 bp, - strand  Genetic Position: Chr3, 38.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97027
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.8-kb of genomic sequence containing the first exon with the initiation codon was replaced with a neo cassette. RT-PCR analysis of total RNA from the spleen and cell surface staining of dendritic cells (DC) confirmed the lack of expression. (J:97027)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema4a Mutation:  21 strains or lines available
References
Original:  J:97027 Kumanogoh A, et al., Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice. Immunity. 2005 Mar;22(3):305-16
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory