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Tpm3tm2Pgun
Targeted Allele Detail
Nomenclature
Symbol: Tpm3tm2Pgun
Name: tropomyosin 3, gamma; targeted mutation 2, Peter Gunning
MGI ID: MGI:3574955
Gene: Tpm3  Location: Chr3:90072649-90100902 bp, + strand  Genetic Position: Chr3, 39.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97192
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance flanked by loxP sites was inserted into the gene, resulting in the deletion of the entire 9c coding and the upstream UTR and splice sites. Western blot confirmed absence of protein from this isoform in mutant brains. (J:97192)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpm3 Mutation:  52 strains or lines available
References
Original:  J:97192 Vrhovski B, et al., Modification of the tropomyosin isoform composition of actin filaments in the brain by deletion of an alternatively spliced exon. Neuropharmacology. 2004 Oct;47(5):684-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory