About   Help   FAQ
Nfe2l1tm1Jefc
Targeted Allele Detail
Nomenclature
Symbol: Nfe2l1tm1Jefc
Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Jefferson Y Chan
MGI ID: MGI:3574931
Synonyms: Nrf1flox
Gene: Nfe2l1  Location: Chr11:96817414-96829968 bp, - strand  Genetic Position: Chr11, 60.12 cM, cytoband D-E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97188
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 3 and a loxP-flanked neo downstream exon 4. An IRES-GFP was at the 3' end of the neo. (J:97188)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l1 Mutation:  10 strains or lines available
References
Original:  J:97188 Xu Z, et al., Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4120-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory