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Spontaneous Allele Detail
Symbol: Apoeshl
Name: apolipoprotein E; spontaneous hyperlipidemia
MGI ID: MGI:3574899
Gene: Apoe  Location: Chr7:19696244-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Xanthoma of Apoeshl/Apoeshl mice

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  KOR
Allele Type:    Spontaneous (Not Specified)
Mutation:    Undefined
Mutation detailsThis mutation was shown to be an allele of Apoe by complementation testing against Apoetm1Unc and by observation of altered restriction fragment sizes upon Southern blot analysis using a partial Apoe cDNA probe. (J:54051)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  88 strains or lines available
Northern blot analysis of liver RNA and immunoblot analysis of plasma from homozygous mice demonstrated lack of expression of Apoe RNA and protein. The phenotype is generally similar to that of targeted Apoe mutations on the same diet. Mice of the original mutant strain (SHL) exhibit more severe xanthoma and hypercholesterolemia, and at an earlier age, than do homozygous mice congenic for the mutation on three standard laboratory inbred-strain backgrounds. In contrast, atherosclerotic lesions of the aortae of congenic mutants are more extensive than those of SHL mice. SHL mice seldom survive past 12 months of age.
Original:  J:54051 Matsushima Y, et al., Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency. Mamm Genome. 1999 Apr;10(4):352-7
All:  10 reference(s)

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