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Zic5tm1Sia
Targeted Allele Detail
Nomenclature
Symbol: Zic5tm1Sia
Name: zinc finger protein of the cerebellum 5; targeted mutation 1, Shinichi Aizawa
MGI ID: MGI:3574814
Synonyms: Opr-
Gene: Zic5  Location: Chr14:122459160-122465658 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97076
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA sequence 172 bp upstream of the zinc finger motif at exon 1 was replaced with a cassette containing stop-IRES-lacZ-loxP-neo-loxP. RT-PCR of mutant embryos confirmed absence of transcript. Crossing with EIIa-cre mice removed the neo. (J:97076)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:  7 strains or lines available
References
Original:  J:97076 Furushima K, et al., Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn. 2005 Apr;232(4):1056-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory