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Targeted Allele Detail
Symbol: Rps6ka5tm1Jsca
Name: ribosomal protein S6 kinase, polypeptide 5; targeted mutation 1, J Simon C Arthur
MGI ID: MGI:3574760
Synonyms: MSK1-
Gene: Rps6ka5  Location: Chr12:100549778-100725028 bp, - strand  Genetic Position: Chr12, 50.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:97140
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo was inserted to replace the ATG and delete the 3' end of exon 1. Western blot of mutants confirmed absence of protein in mutant MEFs. (J:97224)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6ka5 Mutation:  34 strains or lines available
Original:  J:97140 Wiggin GR, et al., MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002 Apr;22(8):2871-81
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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