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Gnrhrhh
Chemically induced Allele Detail
Nomenclature
Symbol: Gnrhrhh
Name: gonadotropin releasing hormone receptor; hypogonadotrophic hypogonadism
MGI ID: MGI:3574585
Gene: Gnrhr  Location: Chr5:86180754-86197901 bp, - strand  Genetic Position: Chr5, 43.56 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis allele has a T to C transition in exon 1, 350 bp downstream of the start codon, causing a leucine to proline substitution at position 117, at the N-terminal junction of the third transmembrane domain. Real-time RT-PCR indicated that mRNA levels are 8-fold higher in homozygous mutants. (J:96941)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnrhr Mutation:  13 strains or lines available
References
Original:  J:96941 Pask AJ, et al., A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol. 2005 Apr;19(4):972-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory