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Transgene Detail
Symbol: Tg(tetO-EGFP/FADD)1Doi
Name: transgene insertion 1, Christophe Benoist
MGI ID: MGI:3574423
Transgene: Tg(tetO-EGFP/FADD)1Doi  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Dominant negative, Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(tetO-EGFP/FADD)1Doi expresses 1 gene
Mutation detailsThe transgene encodes a fusion protein consisting of a truncated, dominant-negative mutant Fas-associated death domain protein in which amino acids 1-79, constituting the death effector domain, have been replaced by the full-length enhanced green fluorescent protein. The coding sequence, preceded by a minimal CMV promoter and a rabbit beta-globin intron and followed by the beta-globin polyadenylation signal, resides downstream of seven copies of the tet operator (tetO). TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline. (J:94935, J:95005)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:95005 Vence L, et al., DN-FADD and Diabetes. Personal Communication. 1995;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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