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Targeted Allele Detail
Symbol: Cfl1tm1.2Wit
Name: cofilin 1, non-muscle; targeted mutation 1.2, Walter Witke
MGI ID: MGI:3574399
Synonyms: deltacof, n-cof-
Gene: Cfl1  Location: Chr19:5490455-5495201 bp, + strand  Genetic Position: Chr19, 4.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:96452
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCfl1tm1Wit mice were crossed to Cre-deleter mice to delete exon 2 and the neo cassette. The deletion created a frame shift and immediate translational stop. Western blot confirmed absence of protein in mutant embryo lysates. (J:96452)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfl1 Mutation:  20 strains or lines available
Original:  J:96452 Gurniak CB, et al., The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory