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Cfl1tm1.1Wit
Targeted Allele Detail
Nomenclature
Symbol: Cfl1tm1.1Wit
Name: cofilin 1, non-muscle; targeted mutation 1.1, Walter Witke
MGI ID: MGI:3574398
Synonyms: flox-Cof, flox n-cof, n-coffl
Gene: Cfl1  Location: Chr19:5490455-5494031 bp, + strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96452
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsCfl1tm1Wit mice were crossed with cre deleter mice to delete the floxed neo, leaving exon 2 flanked with loxP sites. (J:96452, J:125317)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfl1 Mutation:  13 strains or lines available
References
Original:  J:96452 Gurniak CB, et al., The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory