About   Help   FAQ
Hey2tm1Kkb
Targeted Allele Detail
Nomenclature
Symbol: Hey2tm1Kkb
Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Hiroki Kokubo
MGI ID: MGI:3574394
Synonyms: hesr2-
Gene: Hey2  Location: Chr10:30832359-30842801 bp, - strand  Genetic Position: Chr10, 17.19 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97120
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting construct was designed to delete the entire coding region by replacing it with a loxP neo cassette subsequently removed via cre mediated excision. (J:97120)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hey2 Mutation:  14 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Aortic Valve Disease J:216895.

References
Original:  J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory