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Trpv3tm1Apat
Targeted Allele Detail
Nomenclature
Symbol: Trpv3tm1Apat
Name: transient receptor potential cation channel, subfamily V, member 3; targeted mutation 1, Ardem Patapoutian
MGI ID: MGI:3574024
Synonyms: TRPV3-
Gene: Trpv3  Location: Chr11:73267489-73300368 bp, + strand  Genetic Position: Chr11, 45.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96549
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe exons encoding the putative pore region and adjacent transmembrane segments five and six were deleted by homologous recombination. RT-PCR of skin demonstrated that mutants lacked the wild-type protein. Presence of low levels of a truncated transcript was shown. (J:96549)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpv3 Mutation:  8 strains or lines available
Notes
Per a personal communication from the laboratory of Dr. Ardem Patapoutian, the gene was targeted in the R1 embryonic stem cell line, not in the CJ7 line as stated in the original reference for this mutation.
References
Original:  J:96549 Moqrich A, et al., Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 2005 Mar 4;307(5714):1468-72
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory