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Targeted Allele Detail
Symbol: Dclre1ctm2Mcow
Name: DNA cross-link repair 1C; targeted mutation 2, Morton J Cowan
MGI ID: MGI:3574021
Synonyms: mArt-
Gene: Dclre1c  Location: Chr2:3424131-3464130 bp, + strand  Genetic Position: Chr2, 1.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:96535
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6-11, encompassing 80% of the gene, were replaced with a neo. Western blot of lymphoid tissues demonstrated the lack of wild-type protein in mutants. (J:96535)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dclre1c Mutation:  16 strains or lines available
Original:  J:96535 Li L, et al., Targeted disruption of the artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation. J Immunol. 2005 Feb 15;174(4):2420-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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