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Tg(SOD1*G37R)42Dpr
Transgene Detail
Summary
Symbol: Tg(SOD1*G37R)42Dpr
Name: transgene insertion 42, Donald L Price
MGI ID: MGI:3574014
Synonyms: G37R(42), G37R SOD1 line 42, SOD1 G37R line 42, Tg(SOD1-G37R)42Dpr
Transgene: Tg(SOD1*G37R)42Dpr  Location: unknown  
Alliance: Tg(SOD1*G37R)42Dpr page
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SOD1*G37R)42Dpr expresses 1 gene
 
Mutation detailsA 12 kb genomic DNA fragment containing a mutated form of human SOD1 with a glycine to arginine substitution at amino acid 37 (G37R) was used for the transgene. The G37R mutation is found in some cases of familial amyotrophic lateral sclerosis (FALS). (J:69178)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:69178 Wong PC, et al., An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 Jun;14(6):1105-16
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory