Nbwa1^NZB
QTL Variant Detail

Summary

• QTL variant: Nbwa1^NZB
• Name: NZB and NZW autoimmunity 1; NZB
• MGI ID: MGI:3573888
• QTL: Nbwa1 Location: Chr12:17340134-17340302 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 8.06 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZB

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to systemic lupus erythematosus compared to BALB/c. (J:88464)
• Inheritance: Recessive

Notes

This allele shows linkage to increased IgG anti-chromatin, anti-ssDNA, and anti-dsDNA autoantibodies.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:88464

(NZW x BALB/c.H2z)F1 x NZB and (NZB x BALB/c)F2 crosses were used to find loci linked to autoantibody production and glomerulonephritis related to lupus-like autoimmune syndrome. Whereas New Zealand Black (NZB) and New Zealand White (NZW) mice are susceptible to a lupus-like autoimmune syndrome. Serological and histological SLE traits showed linkage to regions on mouse Chromosome 12 (Nbwa1) at D12Mit291 with a LOD greater then 3.6. A region on Mouse chromosome 4 (Sle15) at D4Mit41 was linked to total serum IgM (p = 9.6 x 10-3) and IgG (p = 1.1 x 10-3) at 9.3 and 15.6 cM from the centromere, respectively. Various other novel QTLs were found in mouse Chromosomes 6, 7, 8, 9, and 16.

References

• Original: J:88464 Rigby RJ, et al., New loci from New Zealand Black and New Zealand White mice on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c. J Immunol. 2004 Apr 1;172(7):4609-17
• All: 1 reference(s)