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Pitx3tm1Mli
Targeted Allele Detail
Nomenclature
Symbol: Pitx3tm1Mli
Name: paired-like homeodomain transcription factor 3; targeted mutation 1, Meng Li
MGI ID: MGI:3573869
Synonyms: Pitx3GFP
Gene: Pitx3  Location: Chr19:46124124-46136765 bp, - strand  Genetic Position: Chr19, 38.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96772
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector containing a splice acceptor-eGFP-ires-pac-pA cassette and a floxed PGK-hygro cassette was used to replace exons 2, 3 and half of 4. Expression of a Cre plasmid excised the floxed hygro. (J:96772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 46 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx3 Mutation:  17 strains or lines available
References
Original:  J:96772 Zhao S, et al., Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. Eur J Neurosci. 2004 Mar;19(5):1133-40
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory