Kit^Wads
Chemically induced Allele Detail

Summary

• Symbol: Kit^Wads
• Name: KIT proto-oncogene receptor tyrosine kinase; white anemic deaf sterile
• MGI ID: MGI:3573757
• Synonyms: Wads^m
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^Wads page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was shown by sequence analysis to be a T-to-C transition missense mutation at nucleotide 2567, resulting in a phenylalanine to serine substitution at amino acid 856 of the encoded protein. This conserved residue is located in the second protein tyrosine kinase domain. (J:96391)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 179 strains or lines available

References

• Original: J:96391 Ruan HB, et al., Identification of a Novel Point Mutation of Mouse Proto-Oncogene c-kit Through N-Ethyl-N-nitrosourea Mutagenesis. Genetics. 2005 Feb;169(2):819-31
• All: 5 reference(s)