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Spontaneous Allele Detail
Symbol: Clcn1adr-mto5J
Name: chloride channel, voltage-sensitive 1; myotonia 5 Jackson
MGI ID: MGI:3573744
Gene: Clcn1  Location: Chr6:42286685-42315756 bp, + strand  Genetic Position: Chr6, 20.57 cM
Strain of Origin:  B6;129S-Fcgr2btm1Ttk
Allele Type:    Spontaneous
Mutation:    Undefined
Mutation detailsThis mutation occurred spontaneously in a colony at The Jackson Laboratory in October, 1999. It was shown to be a remutation at Clcn1 by its failure to complement Clcn1adr-mto2J in a complementation test.
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clcn1 Mutation:  9 strains or lines available
Mice homozygous for Clcn1adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.
Original:  J:94340 The Jackson Laboratory Office of Genetic Resources, Registry of Remutation at The Jackson Laboratory. MGI Direct Data Submission. 2000-2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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