Tg(LPV-TAg121)#Tvd
Transgene Detail

Summary

• Symbol: Tg(LPV-TAg121)#Tvd
• Name: transgene insertion #, Terry Van Dyke
• MGI ID: MGI:3531485
• Synonyms: dl1137, LST1137
• Transgene: Tg(LPV-TAg121)#Tvd Location: unknown
• Alliance: Tg(LPV-TAg121)#Tvd page

Transgene origin

• Strain of Origin: (C57BL/6J X DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene consists of a lymphotropic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and the TRP53 binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. (J:80499)

Tumor Data

List all tumor models in MMHCdb carrying Tg(LPV-TAg121)#Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72121 Saenz Robles MT, et al., Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol. 1994 Apr;14(4):2686-98
• All: 3 reference(s)