Mtm1^{Gt(OST290577)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mtm1^{Gt(OST290577)Lex}
• Name: X-linked myotubular myopathy gene 1; gene trap OST290577, Lexicon Genetics
• MGI ID: MGI:3531156
• Synonyms: Mtm1^{Gt(neo)672Lex}
• Gene: Mtm1 Location: ChrX:70254373-70359019 bp, + strand Genetic Position: ChrX, 36.55 cM
• Alliance: Mtm1^{Gt(OST290577)Lex} page

Mutation origin

• Mutant Cell Line: OST290577
• Germline Transmission: Earliest citation of germline transmission: J:192845
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted into intron 1. Western blot analysis confirmed the absence of protein expression in the muscle, liver, heart and brain. (J:192845)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST290577	CG609390 ; (MGI Seq Detail)	3' RACE	ChrX:70274994-70303431 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  18 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtm1 Mutation: 27 strains or lines available

References

• Original: J:192845 Fetalvero KM, et al., Defective autophagy and mTORC1 signaling in myotubularin null mice. Mol Cell Biol. 2013 Jan;33(1):98-110
• All: 2 reference(s)