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Zbtb7bhd
Spontaneous Allele Detail
Nomenclature
Symbol: Zbtb7bhd
Name: zinc finger and BTB domain containing 7B; helper deficient
MGI ID: MGI:3530739
Synonyms: HD-, Th-POK-, ThPOKhd, Zbtb7b-
Gene: Zbtb7b  Location: Chr3:89377644-89393673 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Strain of Origin:  mixed
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsAn A to G mutation at nucleotide position 1165 within the coding region resulted in an arginine to glycine substitution at amino acid position 389. This mutation is within the second of four zinc finger domains and affects a residue predicted to interact directly with DNA. (J:95867)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  19 strains or lines available
Notes
Mutation arose from mixed C57BL/6, BALB/c, C3H, and 129/Sv parentage.
References
Original:  J:48734 Dave VP, et al., HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8187-92
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory