Zbtb7b^hd
Spontaneous Allele Detail

Summary

• Symbol: Zbtb7b^hd
• Name: zinc finger and BTB domain containing 7B; helper deficient
• MGI ID: MGI:3530739
• Synonyms: HD^-, Th-POK^-, ThPOK^hd, Zbtb7b^-
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^hd page

Mutation origin

• Strain of Origin: mixed

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: An A-to-G mutation at coding nucleotide 1165 resulted in an arginine to glycine substitution at amino acid position 389 (p.R389G). This mutation is within the second of four zinc finger domains and affects a residue predicted to interact directly with DNA. (J:95867)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 24 strains or lines available

Notes

Mutation arose from mixed C57BL/6, BALB/c, C3H, and 129/Sv parentage.

References

• Original: J:48734 Dave VP, et al., HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8187-92
• All: 13 reference(s)