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Kiss1rtm1Coll
Targeted Allele Detail
Nomenclature
Symbol: Kiss1rtm1Coll
Name: KISS1 receptor; targeted mutation 1, William H Colledge
MGI ID: MGI:3530566
Synonyms: gpr54-, Gpr54tm1Par, Gpr54tm1PTL
Gene: Kiss1r  Location: Chr10:79916971-79922273 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96442
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-Betagal-MC-neo cassette was inserted into exon 1, replacing the 3' end of exon 1, intron 1 and the 5' end of exon 2. The deleted sequence encoded transmembrane loops 1 and 2 and the encompassing domains. RT-PCR confirmed that the resulting allele was a null. (J:96442)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1r Mutation:  13 strains or lines available
References
Original:  J:96442 Seminara SB, et al., The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23;349(17):1614-27
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory