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Targeted Allele Detail
Symbol: Gjc1tm1Weil
Name: gap junction protein, gamma 1; targeted mutation 1, Reto Weiler
MGI ID: MGI:3530292
Synonyms: Cx45flox
Gene: Gjc1  Location: Chr11:102799579-102819700 bp, - strand  Genetic Position: Chr11, 66.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:95984
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 3 remained flanked by loxP sites following FLP mediated excision of a neo from intron 2. An EGFP was left in intron 3. (J:95984)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjc1 Mutation:  17 strains or lines available
Original:  J:95984 Maxeiner S, et al., Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci. 2005 Jan 19;25(3):566-76
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory