Eae2b^C57BL/10SnSg
QTL Variant Detail

Summary

• QTL variant: Eae2b^C57BL/10SnSg
• Name: experimental allergic encephalomyelitis susceptibility 2b; C57BL/10SnSg
• MGI ID: MGI:3530268
• Synonyms: Eae2b^{B10.RIII-H2r/SgKljLund}
• QTL: Eae2b Location: Chr15:51004694-64944308 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: B10.RIII-H2^r/SgKljLund

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased susceptibility to EAE development compared to RIIIS/J. (J:96204)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Animals homozygous for B10.RIII-derived alleles exhibit the highest area under the curve (AUC).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

On mouse Chromosome 15, a locus including Eae2 (15.5 cM) showed linkage to EAE development (area under the curve-AUC) between markers D15Mit100 (21 cM) and D15Mit234 (34.2 cM). Animals homozygous for B10.RIII-H2^r/SgKljLund-derived alleles exhibit the highest AUC. This inheritance pattern is different from what was previously observed with Eae2. Therefore, this locus is thought to be distinct from Eae2 and has been assigned the symbol Eae2b.

On mouse Chromosome 15, Eae2 shows linkage to CD4+/CD8+ T cell ratios in female animals. This phenotype is linked to marker D15Mit150 (12.1 cMc) with an LRS of 13.3.

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)