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Targeted Allele Detail
Symbol: Adcy10tm1Lex
Name: adenylate cyclase 10; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3529121
Synonyms: Lex/Sacytm1 KO, sAC-, Sacy-, Sacytm1Jgo, Sacytm1Lex, SacytmLex
Gene: Adcy10  Location: Chr1:165312752-165404343 bp, + strand  Genetic Position: Chr1, 72.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:88649
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES-lacZ gene replaced exons 2, 3, and 4. In situ analysis confirmed the absence of endogenous protein in the testis. RT-PCR showed a very low level of transcript expression in the testis that is likely due to read through of the IRES-lacZ cassette. This mutant transcript cannot produce functional protein due to frameshift mutations. (J:88649)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adcy10 Mutation:  54 strains or lines available
See also, data as provided by Lexicon Genetics, Inc.
Original:  J:88649 Esposito G, et al., Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2993-8
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory