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Targeted Allele Detail
Symbol: Nr5a2tm1Lex
Name: nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528835
Synonyms: LRH-1-
Gene: Nr5a2  Location: Chr1:136842571-136960448 bp, - strand  Genetic Position: Chr1, 59.98 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:97625
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsExon 1, containing the ATG start codon was disrupted by the insertion of a Betageo gene. In situ hybridization confirmed loss of expression in mutant embryos. (J:97625)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr5a2 Mutation:  81 strains or lines available
Original:  J:97625 Gu P, et al., Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Mol Cell Biol. 2005 May;25(9):3492-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory