Ikbkb^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm1Lex
• Name: inhibitor of kappaB kinase beta; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528765
• Synonyms: IKKbeta^fl
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159873
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:159873)

Tumor Data

List all tumor models in MMHCdb carrying Ikbkb^tm1Lex

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 54 strains or lines available

References

• Original: J:159873 Penzo M, et al., Inhibitor of NK-kappaB kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis. J Immunol. 2010 Apr 15;184(8):4497-509
• All: 4 reference(s)