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Atrxtm1Rjg
Targeted Allele Detail
Nomenclature
Symbol: Atrxtm1Rjg
Name: ATRX, chromatin remodeler; targeted mutation 1, Richard Gibbons
MGI ID: MGI:3528480
Synonyms: AtrxFl, Atrxflox, AtrxloxP, Atrxtm1Pick
Gene: Atrx  Location: ChrX:105797615-105929403 bp, - strand  Genetic Position: ChrX, 47.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95953
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo was inserted into intron 17 and a loxP sites into intron 18. Excision of this exon would still allow production of the shorter isoform containing exons 1-11. (J:95953, J:115836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atrx Mutation:  77 strains or lines available
References
Original:  J:95953 Berube NG, et al., The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest. 2005 Feb;115(2):258-67
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory