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Targeted Allele Detail
Symbol: Abca12tm1Lex
Name: ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3528440
Gene: Abca12  Location: Chr1:71282249-71454069 bp, - strand  Genetic Position: Chr1, 35.81 cM
Neonatal lethality and epidermal hyperkeratosis in Abca12tm1Lex/Abca12tm1Lex mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:103485
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThere is some discrepancy as to the exact exon tagged (either exon 8, 9 or 10). The dataset provided for this allele incorrectly states that exon 8 was targeted. It has subsequently been determined that exon 10 has been deleted. See references. The absence of protein expression was confirmed by western blot analysis on epidermis extracts. (J:103485, J:144062)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Abca12 Mutation:  76 strains or lines available
See also, data as provided by Lexicon Genetics, Inc.
Original:  J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory