Abca12^tm1Lex
Targeted Allele Detail

Nomenclature

• Symbol: Abca12^tm1Lex
• Name: ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3528440
• Gene: Abca12 Location: Chr1:71282249-71454069 bp, - strand Genetic Position: Chr1, 35.81 cM

Neonatal lethality and epidermal hyperkeratosis in Abca12^tm1Lex/Abca12^tm1Lex mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103485
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: There is some discrepancy as to the exact exon tagged (either exon 8, 9 or 10). The dataset provided for this allele incorrectly states that exon 8 was targeted. It has subsequently been determined that exon 10 has been deleted. See references. The absence of protein expression was confirmed by western blot analysis on epidermis extracts. (J:103485, J:144062)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Abca12 Mutation: 2 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 4 reference(s)