About   Help   FAQ
Targeted Allele Detail
Symbol: Trp53tm3.1Glo
Name: transformation related protein 53; targeted mutation 3.1, Guillermina Lozano
MGI ID: MGI:3528279
Synonyms: p53515A, p53R172H
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Germline Transmission:  Earliest citation of germline transmission: J:95318
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Dominant negative, Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsAn arginine to histidine substitution was generated at codon 172 (R172H, equivalent to R175H in humans) by insertion of a targeting construct containing a floxed PGK-neo cassette and a G to A mutation at nucleotide 515. The floxed selection cassette was excised via cre-mediated recombination, leaving one loxP site in intron 4. Western blot analysis of homozygous MEFs detected mutant protein. (J:95318)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  157 strains or lines available
Original:  J:95318 Lang GA, et al., Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):861-72
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory