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Targeted Allele Detail
Symbol: Trp53tm3.1Glo
Name: transformation related protein 53; targeted mutation 3.1, Guillermina Lozano
MGI ID: MGI:3528279
Synonyms: p53515A, p53R172H
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Germline Transmission:  Earliest citation of germline transmission: J:95318
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Dominant negative, Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsAn arginine to histidine substitution was generated at codon 172 (R172H, equivalent to R175H in humans) by insertion of a targeting construct containing a floxed PGK-neo cassette and a G to A mutation at nucleotide 515. The floxed selection cassette was excised via cre-mediated recombination, leaving one loxP site in intron 4. Western blot analysis of homozygous MEFs detected mutant protein. (J:95318)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  160 strains or lines available
Original:  J:95318 Lang GA, et al., Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):861-72
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory