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Targeted Allele Detail
Symbol: Apodtm1Bres
Name: apolipoprotein D; targeted mutation 1, Jan L Breslow
MGI ID: MGI:3528149
Synonyms: ApoD-, Apodtm1Hhmd
Gene: Apod  Location: Chr16:31115010-31133626 bp, - strand  Genetic Position: Chr16, 21.41 cM
Increased myocardial infraction size following ischemia in Apodtm1Bres/Apodtm1Bres mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:95654
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 2, including the translational start and signal peptide needed for protein secretion, with a neomycin resistance cassette. (J:101977)
Generation of the Apodtm1Bres allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apod Mutation:  17 strains or lines available
Original:  J:95654 Hildebrand MS, et al., Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hear Res. 2005 Feb;200(1-2):102-114
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory