Tg(SFTPC-TP53*R273H)1Mavc
Transgene Detail

Summary

• Symbol: Tg(SFTPC-TP53*R273H)1Mavc
• Name: transgene insertion 1, Miguel A Villalona-Calero
• MGI ID: MGI:3527998
• Synonyms: p53-273H, Tg(SFTPC-TRP53*R273H)1Mavc
• Transgene: Tg(SFTPC-TP53*R273H)1Mavc Location: unknown
• Alliance: Tg(SFTPC-TP53*R273H)1Mavc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 1.8 kb fragment containing a mutant human TP53 with an arginine to histidine mutation at codon 273 was cloned into the EcoRI site of the rabbit Beta-globin exon 3 and placed under the transcriptional control of the human Surfactant associated protein C (SFTPC) promoter. ~7 copies of the transgene were incorporated into the genome. (J:80317)

Tumor Data

List all tumor models in MMHCdb carrying Tg(SFTPC-TP53*R273H)1Mavc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80317 Duan W, et al., Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice. Oncogene. 2002 Nov 7;21(51):7831-8
• All: 2 reference(s)