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Ren1tm3Gom
Targeted Allele Detail
Nomenclature
Symbol: Ren1tm3Gom
Name: renin 1 structural; targeted mutation 3, R Ariel Gomez
MGI ID: MGI:3527932
Synonyms: Ren1d-DTA
Gene: Ren1  Location: Chr1:133350510-133360325 bp, + strand  Genetic Position: Chr1, 57.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95786
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA neo and diphtheria toxin A chain (DTA) replaced exons 1-7. RT-PCR of mutants demonstrated the lack of wild-type transcript and the presence of DTA transcript. (J:95786)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:  22 strains or lines available
References
Original:  J:95786 Pentz ES, et al., Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype. Am J Physiol Regul Integr Comp Physiol. 2004 Mar;286(3):R474-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory