About   Help   FAQ
Due to maintenance, access to MGI maybe intermittent on Thu, May 23 at 7:30 AM ET.
Targeted Allele Detail
Symbol: Cngb1tm1.1Biel
Name: cyclic nucleotide gated channel beta 1; targeted mutation 1.1, Martin Biel
MGI ID: MGI:3527896
Synonyms: GNGB1-
Gene: Cngb1  Location: Chr8:95239045-95306585 bp, - strand  Genetic Position: Chr8, 47.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:95768
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 26 was removed via Cre-mediated excision, leaving a single loxP site. RT-PCR analysis demonstrated no transcript was present in mutant retinas and Western blot using an antibody against the C terminus showed the lack of protein in mutants. (J:95768)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cngb1 Mutation:  35 strains or lines available
Original:  J:95768 Huttl S, et al., Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci. 2005 Jan 5;25(1):130-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory