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Dok1tm1Yyam
Targeted Allele Detail
Nomenclature
Symbol: Dok1tm1Yyam
Name: docking protein 1; targeted mutation 1, Yuji Yamanashi
MGI ID: MGI:3527415
Gene: Dok1  Location: Chr6:83030934-83033471 bp, - strand  Genetic Position: Chr6, 35.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95641
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette was used to replace the entire coding region, including the initiation and termination codons. Immunoblot analysis of splenocyte did not detect protein gene product. (J:95641)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dok1 Mutation:  2 strains or lines available
References
Original:  J:95641 Yamanashi Y, et al., Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev. 2000 Jan 1;14(1):11-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory