Zbtb32^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Zbtb32^tm1Ppp
• Name: zinc finger and BTB domain containing 32; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:3527274
• Synonyms: PLZP^-
• Gene: Zbtb32 Location: Chr7:30289106-30298334 bp, - strand Genetic Position: Chr7, 18.72 cM, cytoband B2-B3
• Alliance: Zbtb32^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95119
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region and 750 bp of 3' flanking sequence encompassing a CpG island was replaced with a neo. Northern blot of mutant testis confirmed the lack of transcript. (J:95119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb32 Mutation: 26 strains or lines available

References

• Original: J:95119 Piazza F, et al., Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Mol Cell Biol. 2004 Dec;24(23):10456-69
• All: 2 reference(s)