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Targeted Allele Detail
Symbol: Calcatm1Rfg
Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1, Robert F Gagel
MGI ID: MGI:3527257
Synonyms: Calca-, Ct/Cgrp-, Ctcgrp null
Gene: Calca  Location: Chr7:114631478-114636357 bp, - strand  Genetic Position: Chr7, 59.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:80827
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced exons 2-5. RT-PCR analysis of mutant thyroid glands confirmed successful transcript ablation. Immunohistochemistry further demonstrated the lack of protein in mutant thyroids. (J:80827)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calca Mutation:  11 strains or lines available
Original:  J:80827 Hoff AO, et al., Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest. 2002 Dec;110(12):1849-57
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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