About   Help   FAQ
Calcatm1Rfg
Targeted Allele Detail
Nomenclature
Symbol: Calcatm1Rfg
Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1, Robert F Gagel
MGI ID: MGI:3527257
Synonyms: Calca-, Ct/Cgrp-, Ctcgrp null
Gene: Calca  Location: Chr7:114631478-114636357 bp, - strand  Genetic Position: Chr7, 59.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80827
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 2-5. RT-PCR analysis of mutant thyroid glands confirmed successful transcript ablation. Immunohistochemistry further demonstrated the lack of protein in mutant thyroids. (J:80827)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calca Mutation:  11 strains or lines available
References
Original:  J:80827 Hoff AO, et al., Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest. 2002 Dec;110(12):1849-57
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory