Adgrv1^tm1Msat
Targeted Allele Detail

Summary

• Symbol: Adgrv1^tm1Msat
• Name: adhesion G protein-coupled receptor V1; targeted mutation 1, Makoto Sato
• MGI ID: MGI:3527179
• Synonyms: Vlgr1^-
• Gene: Adgrv1 Location: Chr13:81243187-81781273 bp, - strand Genetic Position: Chr13, 42.18 cM
• Alliance: Adgrv1^tm1Msat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95518
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 2-4. RT-PCR showed that transcripts from mutant animals lacked these exons, and that exon 1 was ligated to exon 5. A stop codon was created by frame shifting in the resulting truncated mRNA transcribed from the direct connection of exon 1 to exon 5, and would result in a 14 amino acid peptide, if any. (J:95518)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adgrv1 Mutation: 318 strains or lines available

References

• Original: J:95518 Yagi H, et al., Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202
• All: 7 reference(s)