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Adgrv1tm1Msat
Targeted Allele Detail
Nomenclature
Symbol: Adgrv1tm1Msat
Name: adhesion G protein-coupled receptor V1; targeted mutation 1, Makoto Sato
MGI ID: MGI:3527179
Synonyms: Vlgr1-
Gene: Adgrv1  Location: Chr13:81095068-81633154 bp, - strand  Genetic Position: Chr13, 42.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95518
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 2-4. RT-PCR showed that transcripts from mutant animals lacked these exons, and that exon 1 was ligated to exon 5. A stop codon was created by frame shifting in the resulting truncated mRNA transcribed from the direct connection of exon 1 to exon 5, and would result in a 14 amino acid peptide, if any. (J:95518)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adgrv1 Mutation:  166 strains or lines available
References
Original:  J:95518 Yagi H, et al., Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory