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Targeted Allele Detail
Symbol: Agrptm2(DTR)Rpa
Name: agouti related neuropeptide; targeted mutation 2, Richard D Palmiter
MGI ID: MGI:3527177
Synonyms: AgrpDTR
Gene: Agrp  Location: Chr8:106293327-106306477 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
Germline Transmission:  Earliest citation of germline transmission: J:132360
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsThe human diphtheria toxin receptor followed by an IRES-DsRed2 reporter gene was targeted to the Agrp locus to allow conditional killing of these cells. Germ-line, cre-mediated recombination was used to remove the neo cassette. (J:132360)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agrp Mutation:  16 strains or lines available
Original:  J:132360 Luquet S, et al., NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005 Oct 28;310(5748):683-5
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory