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Targeted Allele Detail
Symbol: Thtm5Rpa
Name: tyrosine hydroxylase; targeted mutation 5, Richard D Palmiter
MGI ID: MGI:3527166
Synonyms: Thfs, Thlox/stop
Gene: Th  Location: Chr7:142892776-142899966 bp, - strand  Genetic Position: Chr7, 88.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:110806
Parent Cell Line:  AK18.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed pgk-neo cassette was inserted into intron 1. Presence of this cassette interupts expression of the gene. Cre-mediated recombination restores expression. (J:110806)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Th Mutation:  45 strains or lines available
Original:  J:110806 Hnasko TS, et al., Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8858-63
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory