Tg(Pim1-E2F2)35Rebr
Transgene Detail

Summary

• Symbol: Tg(Pim1-E2F2)35Rebr
• Name: transgene insertion 35, Rene Bernards
• MGI ID: MGI:3527140
• Synonyms: Eu-pp-E2F2, TEF2-33
• Transgene: Tg(Pim1-E2F2)35Rebr Location: unknown
• Alliance: Tg(Pim1-E2F2)35Rebr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pim1-E2F2)35Rebr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  E2F1 (1869)

  E2f1	(MGI:101941)

• Tg(Pim1-E2F2)35Rebr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pim1 (MGI:97584)

• Mutation details: A human E2F2 cDNA was cloned downstream of a murine Pim1 promoter in which a duplicated immunoglobulin heavy chain enhancer sequence was inserted. The polyA sequence was contributed by the Molony murine leukemia virus. (J:88864)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pim1-E2F2)35Rebr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88864 Scheijen B, et al., High incidence of thymic epithelial tumors in E2F2 transgenic mice. J Biol Chem. 2004 Mar 12;279(11):10476-83
• All: 1 reference(s)