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Sim1tm1.1Az
Targeted Allele Detail
Nomenclature
Symbol: Sim1tm1.1Az
Name: single-minded homolog 1 (Drosophila); targeted mutation 1.1, Andrew R Zinn
MGI ID: MGI:3526899
Synonyms: Sim1-
Gene: Sim1  Location: Chr10:50895651-50989152 bp, + strand  Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95410
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsPart of exon 1, including the translation start site and the first 17 amino acids encoding the basic domain were deleted upon cre mediated excision of a floxed sequence encompassing the ATG and a neo inserted into intron 1. (J:95410)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim1 Mutation:  30 strains or lines available
References
Original:  J:95410 Holder JL Jr, et al., Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E105-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory