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Mybpc3tm1Rmos
Targeted Allele Detail
Nomenclature
Symbol: Mybpc3tm1Rmos
Name: myosin binding protein C, cardiac; targeted mutation 1, Richard L Moss
MGI ID: MGI:3526881
Synonyms: cMyBP-C-
Gene: Mybpc3  Location: Chr2:91118144-91136516 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95725
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 10 were replaced with a neomycin resistance cassette. Truncated transcription products were identified by Northern blot analysis. No protein products could be identified on Western blots. (J:95725)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mybpc3 Mutation:  24 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or AB2.2 (129S7/SvEvBrd-Hprtb-m2).
References
Original:  J:95725 Harris SP, et al., Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res. 2002 Mar 22;90(5):594-601
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory