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Icostm1Tkan
Targeted Allele Detail
Nomenclature
Symbol: Icostm1Tkan
Name: inducible T cell co-stimulator; targeted mutation 1, T Kanai
MGI ID: MGI:3526880
Synonyms: ICOS-, ICOS-KO
Gene: Icos  Location: Chr1:60977927-61000320 bp, + strand  Genetic Position: Chr1, 30.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95728
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin-resistance gene replaced exon 2. Staining of splenic T cells from mutants confirmed the lack of protein expression. (J:95728)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icos Mutation:  12 strains or lines available
References
Original:  J:95728 Iiyama R, et al., The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunol Lett. 2003 Jul 3;88(1):63-70
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory