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Matktm1Sor
Targeted Allele Detail
Nomenclature
Symbol: Matktm1Sor
Name: megakaryocyte-associated tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID: MGI:3526800
Synonyms: Matk/CHK-
Gene: Matk  Location: Chr10:81252935-81263365 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109203
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA DNA fragment of approximately 500 bp that includes exon 7, which encodes a peptide sequence essential for ATP binding, has been replaced by a neomycin resistance cassette. (J:109203)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Matk Mutation:  21 strains or lines available
References
Original:  J:109203 Lee BC, et al., Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice. Blood. 2006 Aug 1;108(3):904-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory