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Slc6a1tm1.1Lst
Targeted Allele Detail
Nomenclature
Symbol: Slc6a1tm1.1Lst
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1.1, Henry A Lester
MGI ID: MGI:3526736
Gene: Slc6a1  Location: Chr6:114282635-114317525 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80438
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe floxed neomycin cassette in intron 14 was removed via cre mediated recombination. A GFP gene was inserted in exon 15 at the 3' end of the coding sequence. Expression of the GFP fusion protein is similar to wild-type. (J:80438)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a1 Mutation:  33 strains or lines available
References
Original:  J:80438 Chiu CS, et al., Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci. 2002 Dec 1;22(23):10251-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory