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Rdh11tm1Tsyk
Targeted Allele Detail
Nomenclature
Symbol: Rdh11tm1Tsyk
Name: retinol dehydrogenase 11; targeted mutation 1, Tom S Y Kim
MGI ID: MGI:3526658
Synonyms: Rdh11tm1Kpal
Gene: Rdh11  Location: Chr12:79174337-79192293 bp, - strand  Genetic Position: Chr12, 35.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97788
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsTargeted disruption of RDH11 resulted in the replacement of exons 2 and 3 with the neomycin gene. Exon 2 contains the NADPH binding site. Any resulting transcript from exon 1 would be 22 amino acids long. Alternative splicing from this exon to any of exons 4-7 would cause a frameshift resulting in a premature stop codon. Immunoblotting demonstrated the loss of protein from mutant testes. Transcript was not found in mutant liver tissue. (J:97788)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh11 Mutation:  4 strains or lines available
References
Original:  J:97788 Kim TS, et al., Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005 Mar 11;280(10):8694-704
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory