About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Parltm1Bdes
Targeted Allele Detail
Nomenclature
Symbol: Parltm1Bdes
Name: presenilin associated, rhomboid-like; targeted mutation 1, Bart De Strooper
MGI ID: MGI:3526574
Gene: Parl  Location: Chr16:20279818-20302387 bp, - strand  Genetic Position: Chr16, 12.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116017
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sequences were inserted into intron 2 and intron 3. (J:116017)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Parl Mutation:  25 strains or lines available
References
Original:  J:116017 Cipolat S, et al., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 2006 Jul 14;126(1):163-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/05/2019
MGI 6.14
The Jackson Laboratory