Tg(Nr0b1-Sry)23Rlb
Transgene Detail

Summary

• Symbol: Tg(Nr0b1-Sry)23Rlb
• Name: transgene insertion 23, Robin Lovell-Badge
• MGI ID: MGI:3526560
• Synonyms: D:S23
• Transgene: Tg(Nr0b1-Sry)23Rlb Location: unknown
• Alliance: Tg(Nr0b1-Sry)23Rlb page

Transgene origin

• Strain of Origin: CBAB10F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Nr0b1-Sry)23Rlb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sry (MGI:98660)

• Mutation details: An 11 kb fragment of the Nr0b1 regulatory region drives expression of 5kb of murine Sry genomic DNA. Two lines were generated which showed partial (line 8) or complete (line 23) penetrance of sex reversal. Line 23 was selected for further study. (J:45884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:45884 Swain A, et al., Dax1 antagonizes Sry action in mammalian sex determination. Nature. 1998 Feb 19;391(6669):761-7
• All: 1 reference(s)